A human brain model with illuminated purple hues against a purple background.

Brain Health, Cognition, and Mental Wellbeing

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  3. Pratt J, et al. Intra- and inter-session reliability and repeatability of 1H magnetic resonance spectroscopy for determining total creatine concentrations in multiple brain regions. Experimental Physiology, 2025.

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  5. Smith AN, et al. Creatine monohydrate pilot in Alzheimer's: Feasibility, brain creatine, and cognition. Alzheimer's Dement, 2025.

  6. Candow DG, et al. Creatine Supplementation and the Brain: Have We Put the Cart Before the Horse? Journal of Dietary Supplements, 2026.

  7. Candow DG, et al. “Heads Up” for Creatine Supplementation and its Potential Applications for Brain Health and Function. Sports Med, 2023.

  8. Gordji-Nejad A, et al. Single dose creatine improves cognitive performance and induces changes in cerebral high energy phosphates during sleep deprivation. Sci Rep, 2024.

  9. Faulkner P, et al. Relationship between depression, prefrontal creatine and grey matter volume. Journal of Psychopharmacology, 2021.

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  13. Gordji-Nejad A, et al. Single dose creatine improves cognitive performance... during sleep deprivation. Sci Rep, 2024.

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  15. Bian X, et al. Evidence suggesting creatine as a new central neurotransmitter. eLife, 2023.

  16. Xiao Y, et al. Creatine for Parkinson's disease. Cochrane Database Syst Rev, 2014.

  17. Jeryous Fares B, et al. The Effect of Creatine Monohydrate on Mental Disorders: A Systematic Review of Randomized Controlled Trials. The Canadian Journal of Psychiatry, 2026. NEW!

  18. Pratt J, et al. Strenuous Exercise Alters Brain Creatine and Glutamate/Glutamine (Glx) in Humans: Evidence From Dynamic 1H-MRS and 1H-MRSI. The FASEB Journal, 2026. NEW!

  19. Pratt J, et al. Creatine supplementation and brain health: Methodological challenges, current evidence, and translational perspectives. The Journal of Nutritional Physiology, Volume 5, 100017, 2026. NEW!